Endocrine Abstracts

Glycemic variability (GV), a complex phenomenon affecting subjects with diabetes, is one of the main contributors to the risk to develop both acute and long-term complications in type 1 (T1D) and type 2 (T2D) subjects. DNA double-strand breaks, apoptosis, overgeneration of reactive oxygen species (ROS) and the induction of some regulatory micro-RNAs, sustain the ominous mechanisms mainly attributable to GV. The characteristic cellular phenotype induced by GV is scarcely define...